Great peace have they which love thy law: and nothing shall offend them. Psalms 119:165
Many times, we are told this verse means that we should not let anything bother, irritate, or upset us, for if something does bother, irritate, or upset us, then we must not love God’s law. That is not what is conveyed by the word offend however. This verse is meant to be an encouragement to those who love God’s law. It tells us that if we love God’s law, nothing will cause us to stumble from keeping God’s law – no temptation will cause disobedience – nothing will get in our way of serving God.
This verse does not say that loving God’s law is a guarantee that we will never be bothered, irritated, or upset.
To see how offend is used in the sense of breaking God’s law or sinning, see James 2:10 and 1 Corinthians 8:13.
Wherefore, if meat make my brother to offend, I will eat no flesh while the world standeth, lest I make my brother to offend. 1 Corinthians 8:13
For whosoever shall keep the whole law, and yet offend in one point, he is guilty of all. James 2:10